Gerrit Jansen Selected Research

Drug Therapy (Chemotherapy)

1/2021	Pre-Clinical Evaluation of the Proteasome Inhibitor Ixazomib against Bortezomib-Resistant Leukemia Cells and Primary Acute Leukemia Cells.
3/2020	Glucocorticoid Resistant Pediatric Acute Lymphoblastic Leukemia Samples Display Altered Splicing Profile and Vulnerability to Spliceosome Modulation.
1/2019	Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma.
11/2016	Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors.
4/2016	Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance.
12/2011	The impact of folate status on the efficacy of colorectal cancer treatment.
1/2007	Drug Insight: resistance to methotrexate and other disease-modifying antirheumatic drugs--from bench to bedside.
12/2006	Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.

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Gerrit Jansen Research Topics

Disease

29	Rheumatoid Arthritis 10/2023 - 07/2004
27	Neoplasms (Cancer) 01/2023 - 05/2003
22	Leukemia 01/2021 - 01/2002
13	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2023 - 02/2004
11	Breast Neoplasms (Breast Cancer) 01/2019 - 02/2003
9	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2023 - 07/2011
7	Arthritis (Polyarthritis) 01/2022 - 03/2013
7	Hematologic Neoplasms (Hematological Malignancy) 01/2018 - 03/2013
7	Multiple Myeloma 12/2017 - 09/2008
6	Inflammation (Inflammations) 03/2019 - 11/2009
5	Autoimmune Diseases (Autoimmune Disease) 01/2023 - 11/2009
5	Heart Arrest (Cardiac Arrest) 01/2022 - 02/2012
5	Mesothelioma 01/2020 - 08/2003
4	Out-of-Hospital Cardiac Arrest 05/2024 - 12/2021
4	Carcinoma (Carcinomatosis) 05/2014 - 03/2003
4	Colonic Neoplasms (Colon Cancer) 12/2011 - 08/2003
3	COVID-19 01/2023 - 12/2021
3	Lung Neoplasms (Lung Cancer) 04/2014 - 08/2013
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2012 - 08/2003
2	Pain (Aches) 05/2024 - 12/2023
2	Infections 01/2023 - 01/2023
2	Sepsis (Septicemia) 10/2021 - 01/2021
2	Fistula 10/2021 - 10/2021
2	Lymphoma (Lymphomas) 01/2020 - 04/2016
2	Myeloid Leukemia (Leukemia, Myelocytic) 01/2020 - 02/2016
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2019 - 01/2015
2	Carcinogenesis 05/2015 - 08/2013
2	Synovitis 03/2014 - 03/2013
2	Colorectal Neoplasms (Colorectal Cancer) 12/2011 - 06/2007
2	Hereditary Folate Malabsorption 08/2009 - 09/2008
2	T-Cell Leukemia (Leukemia, T Cell) 04/2009 - 07/2008
2	Hypersensitivity (Allergy) 02/2003 - 02/2003
1	Wounds and Injuries (Trauma) 12/2023
1	Colic (Abdominal Cramps) 12/2023
1	Hypotension (Low Blood Pressure) 12/2023
1	Virus Diseases (Viral Diseases) 01/2023

Drug/Important Bio-Agent (IBA)

33	Methotrexate (Mexate)FDA LinkGeneric 10/2023 - 01/2002
29	Folic Acid (Vitamin M)FDA LinkGeneric 01/2022 - 01/2002
22	Proteins (Proteins, Gene)FDA Link 01/2020 - 02/2003
18	Bortezomib (Velcade)FDA Link 01/2021 - 09/2008
16	Proteasome InhibitorsIBA 01/2021 - 09/2008
12	Folic Acid AntagonistsIBA 01/2023 - 01/2002
12	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021 - 07/2010
12	multidrug resistance-associated protein 1IBA 01/2019 - 02/2003
6	folylpolyglutamate synthetaseIBA 01/2021 - 02/2003
6	EnzymesIBA 10/2019 - 02/2003
6	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2019 - 02/2003
5	Pemetrexed (MTA)FDA Link 01/2021 - 01/2002
5	Thymidylate SynthaseIBA 01/2019 - 01/2002
5	Messenger RNA (mRNA)IBA 11/2016 - 08/2003
4	AminopeptidasesIBA 01/2023 - 04/2014
4	poly(ethylene glycol)-folateIBA 01/2020 - 03/2013
3	Amino Acids FDA Link 01/2023 - 08/2009
3	NucleotidesIBA 01/2023 - 04/2009
3	Folate Receptor 2IBA 01/2022 - 01/2009
3	RNA Precursors (Precursor, mRNA)IBA 01/2021 - 05/2015
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2017
3	GlucocorticoidsIBA 03/2020 - 10/2007
3	Proton-Coupled Folate TransporterIBA 01/2020 - 09/2008
3	Adenosine Triphosphate (ATP)IBA 01/2019 - 01/2007
3	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2019 - 06/2004
3	LigandsIBA 01/2019 - 03/2013
3	methylated bovine serum albumin (MBSA)IBA 01/2018 - 03/2014
3	UbiquitinIBA 01/2018 - 08/2013
3	carfilzomibIBA 01/2014 - 04/2012
3	Leucovorin (Folinic Acid)FDA Link 12/2011 - 02/2003
3	7-hydroxymethotrexateIBA 04/2009 - 12/2004
3	Reduced Folate Carrier ProteinIBA 04/2006 - 02/2004
2	methotrexate polyglutamateIBA 01/2023 - 01/2019
2	Oxygen (Dioxygen)IBA 01/2023 - 12/2021
2	CarbonIBA 01/2021 - 03/2019
2	RNA Splicing FactorsIBA 12/2020 - 05/2015
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2020 - 12/2013
2	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2020 - 01/2020
2	AntibodiesIBA 01/2018 - 01/2015
2	DNA (Deoxyribonucleic Acid)IBA 11/2016 - 02/2004
2	ProdrugsIBA 02/2016 - 04/2014
2	Rituximab (Mabthera)FDA Link 03/2015 - 01/2013
2	Antirheumatic Agents (DMARD)IBA 01/2015 - 04/2012
2	CytokinesIBA 01/2015 - 07/2011
2	(R)- (11C)1- (2- chlorophenyl)- N- methyl- N- (1- methylpropyl)- 3- isoquinolinecarboxamideIBA 01/2015 - 03/2013
2	PR-957IBA 01/2014 - 12/2013
2	Ligases (Synthetase)IBA 08/2013 - 04/2009
2	Fluorouracil (Carac)FDA LinkGeneric 12/2011 - 06/2007
2	Mitoxantrone (Novantrone)FDA LinkGeneric 01/2007 - 06/2004
2	N(alpha)- (4- amino- 4- deoxypteroyl)- N(delta)- hemiphthaloyl- L- ornithine (PT 523)IBA 04/2006 - 01/2002
1	Morphine (MS Contin)FDA LinkGeneric 05/2024
1	Analgesics (Analgesic Drugs)IBA 12/2023
1	Acetaminophen (Paracetamol)FDA LinkGeneric 12/2023
1	Nalbuphine (Nubain)FDA LinkGeneric 12/2023
1	Butylscopolammonium Bromide (Butylscopolamine)IBA 12/2023
1	EsketamineIBA 12/2023
1	Mevalonic Acid (Mevalonate)IBA 01/2023

Therapy/Procedure

25	Therapeutics 05/2024 - 07/2004
8	Drug Therapy (Chemotherapy) 01/2021 - 12/2006
4	Resuscitation 01/2023 - 04/2020
3	Airway Management 01/2024 - 12/2021
3	Combination Drug Therapy (Combination Chemotherapy) 04/2014 - 02/2004
1	Analgesia 05/2024
1	Anesthesia 05/2024